abstract：BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...

journal_title：Cancer

authors： Mirkin KA,Greenleaf EK,Hollenbeak CS,Wong J

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data are frequently used to examine receipt of adjuvant radiotherapy (RT), but to the authors' knowledge the accuracy of data regarding second-course treatments is unknown. METHODS:Using SEER-Medicare-linked data, the authors identified a cohort of men who ...

journal_title：Cancer

authors： Wang K,Sheets NC,Basak R,Chen RC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Investigations regarding the impact of tumor biology after surgical management of colorectal liver metastasis have focused largely on overall survival. We investigated the impact of codon-specific KRAS mutations on the rates and patterns of recurrence in patients after surgery for colorectal liver metastasis...

journal_title：Cancer

authors： Margonis GA,Kim Y,Sasaki K,Samaha M,Amini N,Pawlik TM

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan-PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum...

journal_title：Cancer

authors： McKay RR,De Velasco G,Werner L,Bellmunt J,Harshman L,Sweeney C,Rosenberg JE,Hirsch M,Signoretti S,Van Allen EM,Walsh M,Vaishampayan U,McDermott DF,Choueiri TK

更新日期：2016-08-01 00:00:00

abstract：:Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melano...

journal_title：Cancer

authors： Chattopadhyay C,Kim DW,Gombos DS,Oba J,Qin Y,Williams MD,Esmaeli B,Grimm EA,Wargo JA,Woodman SE,Patel SP

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:In the United States, neoadjuvant chemoradiotherapy (NACRT) is widely accepted as the standard of care in the treatment of patients with locally advanced rectal cancer. In the current study, the authors attempted to examine patterns of treatment in the United States over the past decade. METHODS:Using the N...

journal_title：Cancer

authors： Sineshaw HM,Jemal A,Thomas CR Jr,Mitin T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...

journal_title：Cancer

authors： Viani GA,Viana BS,Martin JE,Rossi BT,Zuliani G,Stefano EJ

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...

journal_title：Cancer

authors： Borthakur G,Popplewell L,Boyiadzis M,Foran J,Platzbecker U,Vey N,Walter RB,Olin R,Raza A,Giagounidis A,Al-Kali A,Jabbour E,Kadia T,Garcia-Manero G,Bauman JW,Wu Y,Liu Y,Schramek D,Cox DS,Wissel P,Kantarjian H

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominen...

journal_title：Cancer

authors： Geyer HL,Andreasson B,Kosiorek HE,Dueck AC,Scherber RM,Martin KA,Butler KA,Harrison CN,Radia DH,Cervantes F,Kiladjian JJ,Reiter A,Birgegard G,Passamonti F,Senyak Z,Vannucchi AM,Paoli C,Xiao Z,Samuelsson J,Mesa RA

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the source of advanced cancer patients' information about their prognosis and determine whether this source of information could explain racial disparities in the accuracy of patients' life expectancy estimates (LEEs). METHODS:Coping With Cancer was a prospective, ...

journal_title：Cancer

authors： Trevino KM,Zhang B,Shen MJ,Prigerson HG

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Little is known about the natural growth characteristics of untreated glioblastoma before surgical or therapeutic intervention, because patients are rapidly treated after preliminary radiographic diagnosis. Understanding the growth characteristics of uninhibited human glioblastoma may be useful for character...

journal_title：Cancer

authors： Ellingson BM,Nguyen HN,Lai A,Nechifor RE,Zaw O,Pope WB,Yong WH,Nghiemphu PL,Liau LM,Cloughesy TF

更新日期：2016-06-01 00:00:00

abstract：:In recent years, an increased understanding of T-cell-regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies-even those that historically were not believed to be sensitive to immune therapy. With this, t...

journal_title：Cancer

authors： Salama AK,Postow MA,Salama JK

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:If some adenomas do not bleed over several years, they will cause systematic false-negative fecal immunochemical test (FIT) results. The long-term effectiveness of FIT screening has been estimated without accounting for such systematic false-negativity. There are now data with which to evaluate this issue. ...

journal_title：Cancer

authors： van der Meulen MP,Lansdorp-Vogelaar I,van Heijningen EM,Kuipers EJ,van Ballegooijen M

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest h...

journal_title：Cancer

authors： Cracchiolo JR,Baxi SS,Morris LG,Ganly I,Patel SG,Cohen MA,Roman BR

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND:The months immediately after the completion of treatment for childhood acute lymphoblastic leukemia (ALL) are often regarded as a stressful time for children and families. In this prospective, longitudinal study, the prevalence and predictors of anxiety and depressive symptoms after the completion of treatme...

journal_title：Cancer

authors： Kunin-Batson AS,Lu X,Balsamo L,Graber K,Devidas M,Hunger SP,Carroll WL,Winick NJ,Mattano LA Jr,Maloney KW,Kadan-Lottick NS

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND:The Australian National Cervical Screening Program, introduced more than 20 years ago, does not record the Indigenous status of screening participants. This article reports the first population-based estimates of participation in cervical screening for Indigenous and non-Indigenous Australian women. METHODS...

journal_title：Cancer

authors： Whop LJ,Garvey G,Baade P,Cunningham J,Lokuge K,Brotherton JM,Valery PC,O'Connell DL,Canfell K,Diaz A,Roder D,Gertig D,Moore SP,Condon JR

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND:A rigorous assessment of the risk of colorectal cancer (CRC) among prostate cancer (PC) survivors that controls for important confounding factors and competing risks is necessary to determine the risk of CRC in this population and to inform screening guidelines. METHODS:With data from Manitoba, Canada, subj...

journal_title：Cancer

authors： Desautels D,Czaykowski P,Nugent Z,Demers AA,Mahmud SM,Singh H

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:Widespread disparities in care have been documented in women with gynecologic cancer in the United States. This study was designed to determine whether structural barriers to optimal care were present during the preoperative period for patients with gynecologic cancer. METHODS:A retrospective review was con...

journal_title：Cancer

authors： Frey MK,Moss HA,Musa F,Rolnitzky L,David-West G,Chern JY,Boyd LR,Curtin JP

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:MYCN gene amplification (MNA) is a hallmark of aggressive neuroblastoma. This study was performed to determine univariate and multivariate predictors of tumor MNA. METHODS:Data from the International Neuroblastoma Risk Group were analyzed for a subset of 7102 patients with known MYCN status. Chi-square test...

journal_title：Cancer

authors： Thompson D,Vo KT,London WB,Fischer M,Ambros PF,Nakagawara A,Brodeur GM,Matthay KK,DuBois SG

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS:We conduc...

journal_title：Cancer

authors： El-Jawahri AR,Vandusen HB,Traeger LN,Fishbein JN,Keenan T,Gallagher ER,Greer JA,Pirl WF,Jackson VA,Spitzer TR,Chen YB,Temel JS

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS:Adult MM patients diagnosed between 1973 and 2011 were identified...

journal_title：Cancer

authors： Ailawadhi S,Advani P,Yang D,Ghosh R,Swaika A,Roy V,Foran J,Colon-Otero G,Chanan-Khan A

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:The authors hypothesized that comprehensive genomic profiling of advanced-stage cutaneous squamous cell carcinoma (cSCC) could identify genomic-derived drug targets of therapy for patients with conventional therapy-resistant disease. METHODS:Comprehensive genomic profiling of 315 cancer genes was applied to...

journal_title：Cancer

authors： Al-Rohil RN,Tarasen AJ,Carlson JA,Wang K,Johnson A,Yelensky R,Lipson D,Elvin JA,Vergilio JA,Ali SM,Suh J,Miller VA,Stephens PJ,Ganesan P,Janku F,Karp DD,Subbiah V,Mihm MC,Ross JS

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Adenocarcinomas of the appendix represent a heterogeneous disease depending on the presence of mucinous histology, histologic grade, and stage. In the current study, the authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set. METHODS:Patients in th...

journal_title：Cancer

authors： Asare EA,Compton CC,Hanna NN,Kosinski LA,Washington MK,Kakar S,Weiser MR,Overman MJ

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:The objective of this study was to determine whether a very low presenting prostate-specific antigen (PSA) level was associated with greater prostate cancer-specific mortality (PCSM) among men with a Gleason score (GS) of 8 to 10. METHODS:The Surveillance, Epidemiology, and End Results program was used to i...

journal_title：Cancer

authors： Mahal BA,Aizer AA,Efstathiou JA,Nguyen PL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Poor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15-39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resourc...

journal_title：Cancer

authors： Collins CL,Malvar J,Hamilton AS,Deapen DM,Freyer DR

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:This qualitative study investigated the medical decision-making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision-making involvement. METHODS:Interviews were conducted with 40 adolescents between...

journal_title：Cancer

authors： Weaver MS,Baker JN,Gattuso JS,Gibson DV,Sykes AD,Hinds PS

更新日期：2015-12-15 00:00:00

abstract：:The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core quality-of-life (QL) questionnaire. This review investigates how the mo...

journal_title：Cancer

authors： Koller M,Warncke S,Hjermstad MJ,Arraras J,Pompili C,Harle A,Johnson CD,Chie WC,Schulz C,Zeman F,van Meerbeeck JP,Kuliś D,Bottomley A,European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group.,EO

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Optic pathway gliomas (OPGs) are commonly noted in pediatric oncology services. Radiotherapy is effective at controlling tumors, but has many undesirable late effects, especially in patients with neurofibromatosis. Chemotherapy is commonly used to preserve vision and delay or eliminate the need for radiother...

journal_title：Cancer

authors： Dodgshun AJ,Elder JE,Hansford JR,Sullivan MJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Systematic symptom assessment is not routinely performed in pediatric oncology. The objectives of the current study were to characterize the symptoms of pediatric oncology outpatients and evaluate agreement between patient and proxy reports and the association between children's ratings and oncologists' trea...

journal_title：Cancer

authors： Zhukovsky DS,Rozmus CL,Robert RS,Bruera E,Wells RJ,Chisholm GB,Allo JA,Cohen MZ

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...

journal_title：Cancer

authors： Rodday AM,Parsons SK,Snyder F,Simon MA,Llanos AA,Warren-Mears V,Dudley D,Lee JH,Patierno SR,Markossian TW,Sanders M,Whitley EM,Freund KM

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:There is limited understanding of the association between barriers to care and clinical outcomes within patient navigation programs. METHODS:Secondary analyses of data from the intervention arms of the Patient Navigation Research Program were performed, which included navigated participants with abnormal br...

journal_title：Cancer

authors： Ramachandran A,Snyder FR,Katz ML,Darnell JS,Dudley DJ,Patierno SR,Sanders MR,Valverde PA,Simon MA,Warren-Mears V,Battaglia TA,Patient Navigation Research Program Investigators.

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:The degree of response and the duration of survival of patients treated with mitogen-activated protein kinase (MAPK) inhibitors are highly variable. Whether baseline clinicopathologic factors can predict the clinical course with treatment is largely unknown. METHODS:For 142 consecutive immunotherapy- and MA...

journal_title：Cancer

authors： Menzies AM,Wilmott JS,Drummond M,Lo S,Lyle M,Chan MM,Thompson JF,Guminski A,Carlino MS,Scolyer RA,Kefford RF,Long GV

更新日期：2015-11-01 00:00:00

abstract：:A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...

journal_title：Cancer

authors： Salsman JM,Fitchett G,Merluzzi TV,Sherman AC,Park CL

更新日期：2015-11-01 00:00:00

abstract：:Religion and spirituality (R/S) play an important role in the daily lives of many cancer patients. There has been great interest in determining whether R/S factors are related to clinically relevant health outcomes. In this meta-analytic review, the authors examined associations between dimensions of R/S and social he...

journal_title：Cancer

authors： Sherman AC,Merluzzi TV,Pustejovsky JE,Park CL,George L,Fitchett G,Jim HS,Munoz AR,Danhauer SC,Snyder MA,Salsman JM

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Patients with advanced cancer often experience fatigue and other symptoms that negatively impact their quality of life. The current trial investigated the effect of melatonin on fatigue and other symptoms in patients with advanced cancer. METHODS:Patients who were aged ≥18 years, had a histologically confir...

journal_title：Cancer

authors： Lund Rasmussen C,Klee Olsen M,Thit Johnsen A,Petersen MA,Lindholm H,Andersen L,Villadsen B,Groenvold M,Pedersen L

更新日期：2015-10-15 00:00:00

abstract：:Survivors of pediatric and young adult cancers remain at risk for subsequent diseases, including those related to human papillomavirus (HPV) infection. Prevention of HPV acquisition through vaccination has become possible over the last decade. HPV vaccines have been shown to be safe and effective, yet rates of vaccina...

journal_title：Cancer

authors： Temkin SM,Seibel NL

更新日期：2015-10-01 00:00:00

abstract：:Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorde...

journal_title：Cancer

authors： Prat J,FIGO Committee on Gynecologic Oncology.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...

journal_title：Cancer

authors： Campanella C,Rappa F,Sciumè C,Marino Gammazza A,Barone R,Bucchieri F,David S,Curcurù G,Caruso Bavisotto C,Pitruzzella A,Geraci G,Modica G,Farina F,Zummo G,Fais S,Conway de Macario E,Macario AJ,Cappello F

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...

journal_title：Cancer

authors： Reckamp KL,Koczywas M,Cristea MC,Dowell JE,Wang HJ,Gardner BK,Milne GL,Figlin RA,Fishbein MC,Elashoff RM,Dubinett SM

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC). Furthermore,...

journal_title：Cancer

authors： Li MY,Yuan HL,Ko FW,Wu B,Long X,Du J,Wu J,Ng CS,Wan IY,Mok TS,Hui DS,Underwood MJ,Chen GG

更新日期：2015-09-01 00:00:00